We are building a platform to unlock early detection of disease. Destruction of healthy and diseased cells is a hallmark of all disease. Our technology utilizes epigenomic profiles to detect these events in cell-free DNA.


953 Indiana St, San Francisco CA, 94107

415-322-3343

info@ravel.bio

Our Team

Nathan Boley, Ph.D.

Nathan Boley, Ph.D.

Co-Founder and CEO

Nathan co-founded Ravel and secured its Seed funding in 2019. Nathan was the VP of Technology at Driver where he led the software engineering and R&D teams to develop a cfDNA assay for the identification of somatic variants. He was a contributing computational biologist in the Data Analysis group for the ENCODE and modENCODE projects resulting in publications in Science and Nature. Nathan received his PhD from UC Berkeley in biostatistics where he developed statistical methods for the analysis of functional genomic data under Peter Bickel. As a postdoc in Anshul Kundaje’s lab at Stanford, he developed deep learning models for the analysis of DNA-protein binding events. In his free time, he enjoys spending time with his family.

Paul Giresi, Ph.D.

Paul Giresi, Ph.D.

CSO

Paul is the Chief Scientific Officer at Ravel and is leading efforts to commercialize our diagnostic products for early disease detection, including devising strategies to address regulatory and stakeholder requirements. Paul has over two decades of experience developing epigenomic technologies and analytic tools for improving human health in both industry and academia. These technologies have been widely adopted across a variety of research efforts, including international consortia formed to investigate the epigenome. As an American Cancer Society fellow at Stanford University he invented ATAC-seq, which has rapidly become the standard for measuring the epigenome. He also was a co-founder of Epinomics, which was based on this technology, and was acquired by 10x Genomics. In his free time, Paul enjoys spending time with family and friends.

Graeme McLean

Graeme McLean

Head of Business Development

Grame leads Business Development at Ravel. He transitioned from bench science to business development at Takara Bio USA, Inc. accepting a role as Sales Manager and advancing in the Business and Corporate Development groups. He was involved in Takara‘s diagnostic portfolio, and managed the company’s OEM partnerships (North America & APAC). Graeme has worked with many of the leading diagnostic and pharma companies in the USA and abroad. Graeme also led commercialization efforts at MIODx, Inc., an immune profiling solutions company utilizing human T-cell receptor profiles to make predictions of an individual’s response to therapeutics. He likes to travel, cook, and ski with his family.

Adam Harvey

Adam Harvey

Senior Scientist, Molecular Biology

Adam is responsible for NGS Assay Development and oversees the cfDNA sample processing Laboratory. He has experience in all stages of clinical and non-clinical development/optimization, technical transfer, and laboratory automation. Before joining Ravel, Adam developed a targeted cfDNA assay for somatic variant detection, which was the initial CLIA-validated product at Driver. Adam also led assay development efforts that were critical to launching colorectal cancer detection test at Freenome Inc. Adam attended UC Berkeley for his undergraduate degree in Biochemistry and Molecular Biology and earned a MSc in Biotechnology at San Francisco State University.
Adam likes spending time in Central America with family and friends, enjoying nature and everything the ocean has to offer.

Omid Shams Solari, Ph.D.

Omid Shams Solari, Ph.D.

AI Lead

Omid is an AI Lead at Ravel Bio. He received his PhD in Statistics from UC Berkeley, under Prof. Peter Bickel’s supervision, where he wrote his thesis on interpretable multi-view learning models applied to high-dimensional multi-omic datasets, which resulted in the packages MuLe, BLOCCS, and SparKLe. In his postdoc with Prof. Bin Yu and Dr. Ben Brown from LBNL, he worked on interpretable AI technologies, specifically interpretable generative models. Prior to his Ph.D., he received his Masters’ degree in Applied Mathematics from UC Berkeley. He has also worked as a freelance statistical consultant for a handful of companies and academics. Statistics, genomics, plants, motorcycles, and world literature are his main passions.

Artur Jaroszewicz, Ph.D.

Artur Jaroszewicz, Ph.D.

Senior Computational Biologist

Artur is the Senior Computational Biologist at Ravel. He is a long-time UCLA Bruin, beginning with his B.S in Math and Computational & Systems Biology. Afterwards, he completed his PhD in Bioinformatics with Dr. Jason Ernst, during which Artur developed novel machine learning methods to study epigenomic controls of gene regulation. He has presented this research at various conferences, including NIPS and ISMB. Artur’s years at UCLA culminated as a mathematics lecturer. After a research internship and consultantship at Freenome, Artur joined Ravel to continue the fight against cancer. In his free time, Artur enjoys climbing, martial arts, petting dogs, and crafting cocktails.

Advisors

Anshul Kundaje, Ph.D.

Anshul Kundaje, Ph.D.

Scientific Co-founder

Anshul Kundaje is an Assistant Professor of Genetics and Computer Science at Stanford University. His primary research area is large-scale computational regulatory genomics. The Kundaje lab specializes in developing statistical and machine learning methods for large-scale integrative analysis of heterogeneous, high-throughput functional genomic and genetic data to decipher regulatory elements and long-range regulatory interactions, learn predictive regulatory network models across individuals, cell-types and species and improve detection and interpretation of natural and disease-associated genetic variation.

Christina Curtis, Ph.D.

Christina Curtis, Ph.D.

Scientific Advisor

Christina Curtis is an Associate Professor of Medicine and Genetics at Stanford University where she leads the Cancer Computational and Systems Biology group and serves as Co-Director of the Molecular Tumor Board at the Stanford Cancer Institute. Her research has helped to redefine the molecular map of breast cancer and led to new paradigms in understanding how human tumors progress. Dr. Curtis is the recipient of the awards from the V Foundation for Cancer Research, STOP Cancer, the AACR and is a Kavli Fellow of the National Academy of Sciences. In 2018 she received the National Institutes of Health Director’s Pioneer Award. Dr. Curtis is the principal investigator on grants from the NIH/NCI, NHGRI, Department of Defense, American Association for Cancer Research, Breast Cancer Research Foundation, Susan G. Komen Foundation and Emerson Collective. She serves on the Editorial Boards of Breast Cancer Research, Cancer Discovery, Carcinogenesis: Integrative Biology, Cell Systems, JCO Precision Oncology and the Journal of Computational Biology.

Stefanie Jeffrey, MD

Stefanie Jeffrey, MD

Scientific Advisor

Stefanie Jeffrey is the Chief of Surgical Oncology Research in the Department of Surgery at Stanford University School of Medicine. Dr. Jeffrey was a founding member of the Stanford-Norway team that pioneered the molecular classification of breast tumors into distinct subtypes, including luminal and basal-like/triple-negative breast cancers. Her research expertise is on molecular profiling, technology development, and liquid biopsy, including investigations of circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), and targeted extracellular vesicles (EVs/exosomes) from patient samples and patient-derived models of breast and metastatic colorectal cancer. Dr. Jeffrey is a thought leader, serving as Co-Chair to the Gordon Research Conference on Liquid Biopsy for Cancer, and authoring perspective pieces in high-profile journals such as Science.

George W. Sledge Jr., M.D.

George W. Sledge Jr., M.D.

Scientific Advisor

George Sledge is professor of Medicine at Stanford University and Chief Scientific Advisor to the Susan B. Komen Foundation. He has also served as a member of the FDA‘s ODAC committee, as chair of the ECOG Breast Cancer Committee, as co-program leader for the Indiana University Simon Cancer Center’s Breast Cancer Program, and as President of the American Society of Clinical Oncology. In addition, at a national level he has served on numerous study sections, ad hoc site visit groups, and research panels, including service on the DOD Breast Cancer Research Program’s Integration Panel. George has expertise and an established track record in the area of breast cancer, stretching from the laboratory to the clinical, higher-level drug development, and regulatory issues. He has devoted much of the past 2 decades in the clinic to the development of novel biologic agents for breast cancer. His clinical drug development experience has spanned Phase I, II and III clinical trials, predominantly in breast cancer. He is cur

We are building a platform to unlock early detection of disease. Destruction of healthy and diseased cells is a hallmark of all disease. Our technology utilizes epigenomic profiles to detect these events in cell-free DNA.

953 Indiana St, San Francisco CA, 94107

415-322-3343

info@ravel.bio

Our Team

Nathan Boley, Ph.D.

Nathan Boley, Ph.D.

Co-Founder and CEO

Nathan co-founded Ravel and secured its Seed funding in 2019. Nathan was the VP of Technology at Driver where he led the software engineering and R&D teams to develop a cfDNA assay for the identification of somatic variants. He was a contributing computational biologist in the Data Analysis group for the ENCODE and modENCODE projects resulting in publications in Science and Nature. Nathan received his PhD from UC Berkeley in biostatistics where he developed statistical methods for the analysis of functional genomic data under Peter Bickel. As a postdoc in Anshul Kundaje’s lab at Stanford, he developed deep learning models for the analysis of DNA-protein binding events. In his free time, he enjoys spending time with his family.

Paul Giresi, Ph.D.

Paul Giresi, Ph.D.

CSO

Paul is the Chief Scientific Officer at Ravel and is leading efforts to commercialize our diagnostic products for early disease detection, including devising strategies to address regulatory and stakeholder requirements. Paul has over two decades of experience developing epigenomic technologies and analytic tools for improving human health in both industry and academia. These technologies have been widely adopted across a variety of research efforts, including international consortia formed to investigate the epigenome. As an American Cancer Society fellow at Stanford University he invented ATAC-seq, which has rapidly become the standard for measuring the epigenome. He also was a co-founder of Epinomics, which was based on this technology, and was acquired by 10x Genomics. In his free time, Paul enjoys spending time with family and friends.

Graeme McLean

Graeme McLean

Head of Business Development

Grame leads Business Development at Ravel. He transitioned from bench science to business development at Takara Bio USA, Inc. accepting a role as Sales Manager and advancing in the Business and Corporate Development groups. He was involved in Takara‘s diagnostic portfolio, and managed the company’s OEM partnerships (North America & APAC). Graeme has worked with many of the leading diagnostic and pharma companies in the USA and abroad. Graeme also led commercialization efforts at MIODx, Inc., an immune profiling solutions company utilizing human T-cell receptor profiles to make predictions of an individual’s response to therapeutics. He likes to travel, cook, and ski with his family.

Adam Harvey

Adam Harvey

Senior Scientist, Molecular Biology

Adam is responsible for NGS Assay Development and oversees the cfDNA sample processing Laboratory. He has experience in all stages of clinical and non-clinical development/optimization, technical transfer, and laboratory automation. Before joining Ravel, Adam developed a targeted cfDNA assay for somatic variant detection, which was the initial CLIA-validated product at Driver. Adam also led assay development efforts that were critical to launching colorectal cancer detection test at Freenome Inc. Adam attended UC Berkeley for his undergraduate degree in Biochemistry and Molecular Biology and earned a MSc in Biotechnology at San Francisco State University.
Adam likes spending time in Central America with family and friends, enjoying nature and everything the ocean has to offer.

Omid Shams Solari, Ph.D.

Omid Shams Solari, Ph.D.

AI Lead

Omid is a AI Lead at Ravel Bio. He received his PhD in Statistics from UC Berkeley, under Prof. Peter Bickel’s supervision, where he wrote his thesis on interpretable multi-view learning models applied to high-dimensional multi-omic datasets, which resulted in the packages MuLe, BLOCCS, and SparKLe. In his postdoc with Prof. Bin Yu and Dr. Ben Brown from LBNL, he worked on interpretable AI technologies, specifically interpretable generative models. Prior to his Ph.D., he received his Masters’ degree in Applied Mathematics from UC Berkeley. He has also worked as a freelance statistical consultant for a handful of companies and academics. Statistics, genomics, plants, motorcycles, and world literature are his main passions.

Artur Jaroszewicz, Ph.D.

Artur Jaroszewicz, Ph.D.

Senior Computational Biologist

Artur is the Senior Computational Biologist at Ravel. He is a long-time UCLA Bruin, beginning with his B.S in Math and Computational & Systems Biology. Afterwards, he completed his PhD in Bioinformatics with Dr. Jason Ernst, during which Artur developed novel machine learning methods to study epigenomic controls of gene regulation. He has presented this research at various conferences, including NIPS and ISMB. Artur’s years at UCLA culminated as a mathematics lecturer. After a research internship and consultantship at Freenome, Artur joined Ravel to continue the fight against cancer. In his free time, Artur enjoys climbing, martial arts, petting dogs, and crafting cocktails.

Advisors

Anshul Kundaje, Ph.D.

Anshul Kundaje, Ph.D.

Scientific Co-founder

Anshul Kundaje is an Assistant Professor of Genetics and Computer Science at Stanford University. His primary research area is large-scale computational regulatory genomics. The Kundaje lab specializes in developing statistical and machine learning methods for large-scale integrative analysis of heterogeneous, high-throughput functional genomic and genetic data to decipher regulatory elements and long-range regulatory interactions, learn predictive regulatory network models across individuals, cell-types and species and improve detection and interpretation of natural and disease-associated genetic variation.

Christina Curtis, Ph.D.

Christina Curtis, Ph.D.

Scientific Advisor

Christina Curtis is an Associate Professor of Medicine and Genetics at Stanford University where she leads the Cancer Computational and Systems Biology group and serves as Co-Director of the Molecular Tumor Board at the Stanford Cancer Institute. Her research has helped to redefine the molecular map of breast cancer and led to new paradigms in understanding how human tumors progress. Dr. Curtis is the recipient of the awards from the V Foundation for Cancer Research, STOP Cancer, the AACR and is a Kavli Fellow of the National Academy of Sciences. In 2018 she received the National Institutes of Health Director’s Pioneer Award. Dr. Curtis is the principal investigator on grants from the NIH/NCI, NHGRI, Department of Defense, American Association for Cancer Research, Breast Cancer Research Foundation, Susan G. Komen Foundation and Emerson Collective. She serves on the Editorial Boards of Breast Cancer Research, Cancer Discovery, Carcinogenesis: Integrative Biology, Cell Systems, JCO Precision Oncology and the Journal of Computational Biology.

Stefanie Jeffrey, MD

Stefanie Jeffrey, MD

Scientific Advisor

Dr. Jeffrey is the Chief of Surgical Oncology Research in the Department of Surgery at Stanford University School of Medicine. Dr. Jeffrey was a founding member of the Stanford-Norway team that pioneered the molecular classification of breast tumors into distinct subtypes, including luminal and basal-like/triple-negative breast cancers. Her research expertise is on molecular profiling, technology development, and liquid biopsy, including investigations of circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), and targeted extracellular vesicles (EVs/exosomes) from patient samples and patient-derived models of breast and metastatic colorectal cancer. Dr. Jeffrey is a thought leader, serving as Co-Chair to the Gordon Research Conference on Liquid Biopsy for Cancer, and authoring perspective pieces in high-profile journals such as Science.

George W. Sledge Jr., M.D.

George W. Sledge Jr., M.D.

Scientific Advisor

George Sledge is professor of Medicine at Stanford University and Chief Scientific Advisor to the Susan B. Komen Foundation. He has also served as a member of the FDA‘s ODAC committee, as chair of the ECOG Breast Cancer Committee, as co-program leader for the Indiana University Simon Cancer Center’s Breast Cancer Program, and as President of the American Society of Clinical Oncology. In addition, at a national level he has served on numerous study sections, ad hoc site visit groups, and research panels, including service on the DOD Breast Cancer Research Program’s Integration Panel. George has expertise and an established track record in the area of breast cancer, stretching from the laboratory to the clinical, higher-level drug development, and regulatory issues. He has devoted much of the past 2 decades in the clinic to the development of novel biologic agents for breast cancer. His clinical drug development experience has spanned Phase I, II and III clinical trials, predominantly in breast cancer. He is currently involved with 18 clinical trials.

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Contact Us

953 Indiana St, San Francisco CA, 94107

415-322-3343

info@ravel.bio

© 2020 Ravel Biotechnology

Contact Us

953 Indiana St, San Francisco CA, 94107

415-322-3343

info@ravel.bio

© 2020 Ravel Biotechnology